肼基甲酸乙酯

Prepare 4-phenylurazole from ethyl carbazate and then oxidize the urazole with gaseous dinitrogen tetroxide to yield 4-phenyl-1,2,4-tri- azoline-3,5-dione la. Modification of the ethyl carbazate procedure in which analytically pure monoalkylhydrazine hydrochlorides were isolated in greater than 90% yield, starting from a ketone or aldehyde. Treatment of primary amines is with chloroamine or hydroxylamine-0-sulfonic acid and the condensation of a carbonyl compound with ethyl carbazate. The FeCl 3 -catalyzed reaction of ethyl carbazate (2 b) proceeded readily to give β-hydroxyester 3 b in better yield. A new one-pot neat synthesis of some 5-aryl-2,4-dihydro-3H-1,2,4-triazol-3-ones through cyclocondensation of ethyl carbazate with aryl nitriles catalyzed by DMAP as an efficient and basic nucleophilic catalyst is described.

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

MFCD00007595

223-903-3

C₃H₈N₂O₂

104.11

44-47°

85-86°/7mm

86°(186°F)

Moisture Sensitive. Ambient temperatures.

Fused solid or crystals

Very soluble in water.

878265

III

25-36/37/38
Toxic if swallowed.Irritating to eyes, respiratory system and skin.

6.1

26-36/37-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

FE2545000

是

 

H300-H315-H319-H335
Fatal if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

P280h-P305+P351+P338-P309-P310
Wear protective gloves/clothing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF exposed or if you feel unwell:Immediately call a POISON CENTER or doctor/physician.