4-羟基喹唑啉

4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.

MFCD00511302

207-735-8

C₈H₆N₂O

146.15

216-219°

Ambient temperatures.

Powder

Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).

118473

22-36/37/38
Harmful if swallowed.Irritating to eyes, respiratory system and skin.

26-36/37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.

VA2300000

 

否

 

H302-H315-H319-H335
Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

P280h-P305+P351+P338
Wear protective gloves/clothing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.