您的位置：首页 > 产品中心 > 478341-55-8， CP-339818
CP-339818
产品别名
478341-55-8
CP-339818
N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H24N2 · HCl |
| Molecular weight | 340.89 |
| MDL number | MFCD09878238 |
| PubChem Substance ID【PubChem化学物质编号】 | 329775008 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | CP-338818 blocks both Kv1.3 and Kv1.4. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain cells. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. CP-339818 is also valuable for the study of Kv1.4 function. |
| Features and Benefits【特点和优势】 | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: >10 mg/mL |
| originator【创始人】 | Wyeth |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl.CCCCC\N=C1/C=CN(Cc2ccccc2)c3ccccc13 |
| InChI | 1S/C21H24N2.ClH/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21;/h4-8,10-14,16H,2-3,9,15,17H2,1H3;1H/b22-20+; |
| InChI key | JIRISCAPZWLWCG-QPNALZDCSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
