您的位置:首页 > 产品中心 > 84211-54-1, Cyclo(7-aminoheptanoyl-Phe-D -Trp-Lys-Thr[Bzl])
Cyclo(7-aminoheptanoyl-Phe-D -Trp-Lys-Thr[Bzl])
产品别名
84211-54-1
Cyclo(7-aminoheptanoyl-Phe-
Cyclosomatostatin
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C44H57N7O6 |
Molecular weight | 779.97 |
MDL number | MFCD00076778 |
PubChem Substance ID【PubChem化学物质编号】 | 24892727 |
NACRES | NA.32 |
Amino Acid Sequence | cyclo-Phe-Trp-Lys-Thr-Bzl |
Application【应用】 | Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) has been used as a somatostatin antagonist to study its effects on sleep in rats to infer the role of endogenous somatostatin in the physiologic modulation of REM sleep (REMS) , as an somatostatin (SST) antagonist to study its effects on elemental-induced intestinal atrophy in rats , as an SST receptor antagonist to eliminate the effect of somatostatin on catecholamine . |
Biochem/physiol Actions【生化/生理作用】 | Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]), also known as cyclosomatostatin. Inhibition of somatostatin receptors by cyclosomatostatin induces catalepsy in rats. Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) (cSSTA) is a cyclic somatostatin (SST) analog and is a somatostatin receptor antagonist. It is involved in blocking the effect of somatostatin, such as airway β-adrenergic function and regulation of acetylcholine release. cSSTA is also involved in blocking the effect of somatostatin of hormone release and corticotropin-releasing factor-induced suppression of gastric emptying. |
产品性质
Quality Level【质量水平】 | 200 |
Assay【测定】 | ≥95% (HPLC) |
form【形式】 | powder |
color【颜色】 | white |
solubility【溶解性】 | H2O: 1 mg/mL, clear, colorless |
storage temp.【储存温度】 | −20℃ |
SMILES string | O=C(N[C@H](C(N[C@@]1([H])[C@@H](C)OCC2=CC=CC=C2)=O)CCCCN)[C@H](NC([C@@H](NC(CCCCCCNC1=O)=O)CC3=CC=CC=C3)=O)CC4=CNC5=C4C=CC=C5 |
InChI | 1S/C44H57N7O6/c1-30(57-29-32-18-8-5-9-19-32)40-44(56)46-25-15-3-2-10-23-39(52)48-37(26-31-16-6-4-7-17-31)42(54)50-38(27-33-28-47-35-21-12-11-20-34(33)35)43(55)49-36(41(53)51-40)22-13-14-24-45/h4-9,11-12,16-21,28,30,36-38,40,47H,2-3,10,13-15,22-27,29,45H2,1H3,(H,46,56)(H,48,52)(H,49,55)(H,50,54)(H,51,53)/t30-,36+,37+,38-,40+/m1/s1 |
InChI key | YHVHQZYJGWGAKN-ZUWUZHNASA-N |
Gene Information | human ... SST(6750) mouse ... SST(20604) rat ... SST(24797) |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |