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Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl])

产品编号:3073139
规格:≥95% (HPLC), powder
CAS NO:84211-54-1
包装规格:1 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
30731391 MG4430
产品别名

84211-54-1

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl])

Cyclosomatostatin

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C44H57N7O6
Molecular weight
779.97
MDL number
MFCD00076778
PubChem Substance ID【PubChem化学物质编号】
24892727
NACRES
NA.32
Amino Acid Sequence
cyclo-Phe-Trp-Lys-Thr-Bzl
Application【应用】
Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) has been used as a somatostatin antagonist to study its effects on sleep in rats to infer the role of endogenous somatostatin in the physiologic modulation of REM sleep (REMS) , as an somatostatin (SST) antagonist to study its effects on elemental-induced intestinal atrophy in rats , as an SST receptor antagonist to eliminate the effect of somatostatin on catecholamine .
Biochem/physiol Actions【生化/生理作用】
Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]), also known as cyclosomatostatin. Inhibition of somatostatin receptors by cyclosomatostatin induces catalepsy in rats.
Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) (cSSTA) is a cyclic somatostatin (SST) analog and is a somatostatin receptor antagonist. It is involved in blocking the effect of somatostatin, such as airway β-adrenergic function and regulation of acetylcholine release. cSSTA is also involved in blocking the effect of somatostatin of hormone release and corticotropin-releasing factor-induced suppression of gastric emptying.
产品性质
Quality Level【质量水平】
200
Assay【测定】
≥95% (HPLC)
form【形式】
powder
color【颜色】
white
solubility【溶解性】
H2O: 1 mg/mL, clear, colorless
storage temp.【储存温度】
−20℃
SMILES string
O=C(N[C@H](C(N[C@@]1([H])[C@@H](C)OCC2=CC=CC=C2)=O)CCCCN)[C@H](NC([C@@H](NC(CCCCCCNC1=O)=O)CC3=CC=CC=C3)=O)CC4=CNC5=C4C=CC=C5
InChI
1S/C44H57N7O6/c1-30(57-29-32-18-8-5-9-19-32)40-44(56)46-25-15-3-2-10-23-39(52)48-37(26-31-16-6-4-7-17-31)42(54)50-38(27-33-28-47-35-21-12-11-20-34(33)35)43(55)49-36(41(53)51-40)22-13-14-24-45/h4-9,11-12,16-21,28,30,36-38,40,47H,2-3,10,13-15,22-27,29,45H2,1H3,(H,46,56)(H,48,52)(H,49,55)(H,50,54)(H,51,53)/t30-,36+,37+,38-,40+/m1/s1
InChI key
YHVHQZYJGWGAKN-ZUWUZHNASA-N
Gene Information
human ... SST(6750)
mouse ... SST(20604)
rat ... SST(24797)
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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