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达卡巴嗪
Dacarbazine
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3074459 | 100 MG | 823 | |||
| 3074459 | 1 G | 3330 |
产品别名
4342-03-4
达卡巴嗪
Dacarbazine
DTIC
5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C6H10N6O |
| Molecular weight | 182.18 |
| EC number【EC 号】 | 224-396-1 |
| MDL number | MFCD00057167 |
| PubChem Substance ID【PubChem化学物质编号】 | 24893683 |
| NACRES | NA.85 |
| Application【应用】 | Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents. |
| Biochem/physiol Actions【生化/生理作用】 | Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis. It is known to induce hepatotoxicity in mice. Dacarbazine is not cell cycle-phase specific. |
| Other Notes【其他说明】 | Keep container tightly closed in a dry and well-ventilated place. |
产品性质
| Quality Level【质量水平】 | 100 |
| form【形式】 | powder or crystals |
| solubility【溶解性】 | 1 M HCl: 50 mg/mL |
| Mode of action【作用机制】 | DNA synthesis | interferes |
| antibiotic activity spectrum【抗生素抗菌谱】 | neoplastics |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CN(C)\N=N\c1[nH]cnc1C(N)=O |
| InChI | 1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+ |
| InChI key | FDKXTQMXEQVLRF-ZHACJKMWSA-N |
| packaging【包装】 | 1 g in glass bottle 100 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H302 + H312 + H332 - H315 - H319 - H335 - H340 - H350 |
| Precautionary Statements | P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
