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DIF-3
产品别名
113411-17-9
DIF-3
Differentiation-inducing factor 3
1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C13H17ClO4 |
| Molecular weight | 272.72 |
| MDL number | MFCD05865230 |
| PubChem Substance ID【PubChem化学物质编号】 | 24724455 |
| General description【一般描述】 | Differentiation-inducing factor-3 (DIF-3) is a monochlorinated metabolite of differentiation-inducing factor-1 (DIF-1), that belongs to the differentiation-inducing factor (DIF) family. |
| Application【应用】 | DIF-3 has been used: as a glycogen synthase kinase-3β (GSK-3β) activator to determine if GSK-3β is required for the anti-inflammatory actions of VU0360172 (VuPAM) in murine microglia, as a phosphorylation inhibitor for GSK-3β to examine the links between activation of protein kinase B (PKB)/GSK-3β/Fyn axis and nuclear factor erythroid 2–related factor 2 (NRF2) retention, as a GSK3β activator to study its effects on the cyclooxygenase 2 (COX2) expression levels in human primary chondrocytes in response to visfatin, as a GSK3β activator to study its effects on the intracellular mechanics along with F-actin and β-tubulin fiber networks in human primary chondrocytes |
| Biochem/physiol Actions【生化/生理作用】 | Differentiation-inducing factor-3 (DIF-3) prevents the proliferation of intestinal cancer cells in vitro and in vivo. It may serve as a novel anti-cancer agent. DIF-3 Inhibits cell cycle by inducing G0/G1 arrest. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥99% (HPLC) |
| form【形式】 | solid |
| solubility【溶解性】 | DMSO: soluble 46 mg/mL |
| SMILES string | CCCCCC(=O)c1c(O)cc(OC)c(Cl)c1O |
| InChI | 1S/C13H17ClO4/c1-3-4-5-6-8(15)11-9(16)7-10(18-2)12(14)13(11)17/h7,16-17H,3-6H2,1-2H3 |
| InChI key | JWBMZIJMSBFBIY-UHFFFAOYSA-N |
| packaging【包装】 | 1 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
