氯丙二酸二甲酯

ClCH(COOCH₃)₂

166.56

1768415

249-275-0

MFCD00042837

24863315

NA.22

Dimethyl chloromalonate (dimethyl 2-chloromalonate) is a dialkyl 2-substituted malonate. Carbanions of dimethyl chloromalonate are reported to react with naphthoquinone derivatives, via vicarious nucleophilic substitution or oxidative nucleophilic substitution of hydrogen processes. Dimethyl chloromalonate is reported to react with hydroquinone and monosubstituted hydroquinones to afford 2-oxido-benzo[b]furan derivatives. Synthesis of dimethyl 2-chloromalonate, via chlorination of dimethyl malonate has been reported.

Dimethyl chloromalonate is suitable for use in the synthesis of 4,5,6-trichloropyrimidine. It may be used in the stereoselective synthesis of highly functionalized nitrocyclopropanes. It may be used in one-pot synthesis of tetra-alkoxycarbonylallylidenetriphenylphosphoranes.

200

94%

4-5% dimethyl dichloromalonate

n20/D 1.437 (lit.)

105-106 ℃/19 mmHg (lit.)

1.305 g/mL at 25 ℃ (lit.)

COC(=O)C(Cl)C(=O)OC

1S/C5H7ClO4/c1-9-4(7)3(6)5(8)10-2/h3H,1-2H3

LNBQBURECUEBKZ-UHFFFAOYSA-N

25, 100 g in glass bottle

GHS05

Danger

H314

P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405

Skin Corr. 1B

8A - Combustible, corrosive hazardous materials

WGK 3

224.6 °F - closed cup

107 ℃ - closed cup

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter