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DS1

产品编号:3080008
规格:≥98% (HPLC)
CAS NO:372497-52-4
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
30800085 MG2800
产品别名

372497-52-4

DS1

4-Chloro-N-[6,8-dibromo-2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl]benzamide

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C18H10Br2ClN3OS
Molecular weight
511.62
MDL number
MFCD01943217
PubChem Substance ID【PubChem化学物质编号】
329798608
Biochem/physiol Actions【生化/生理作用】
δ-GABAA receptors are emerging as an important pharmacological target. DS1 potently (low nM) enhances GABA-evoked currents mediated by α4β3δ receptors. It had little effect on GABA responses mediated by α4β3γ2 receptors. At similar concentrations DS1 directly activates this receptor and is the most potent known agonist of α4β3δ receptors. This compound has an opportunity to be become an agonist golden stardard for δ-GABAA receptors.
DS1 potently (low nM) enhances GABA-evoked currents mediated by GABAA α4β3δ receptor subtype. At similar concentrations, it acts as a direct agonist at this receptor and is the most potent agonist known. It has little effect on GABA responses mediated by α4β3γ2 receptors.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
storage condition【储存条件】
desiccated
color【颜色】
off-white to tan
solubility【溶解性】
DMSO: >10 mg/mL
storage temp.【储存温度】
2-8℃
SMILES string
Clc1ccc(cc1)C(=O)Nc2c(nc3c(Br)cc(Br)cn23)-c4cccs4
InChI
1S/C18H10Br2ClN3OS/c19-11-8-13(20)16-22-15(14-2-1-7-26-14)17(24(16)9-11)23-18(25)10-3-5-12(21)6-4-10/h1-9H,(H,23,25)
InChI key
MEWSBNIVOLYKGU-UHFFFAOYSA-N
packaging【包装】
5, 25 mg in glass bottle
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