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Ephrin-A1/Fc Chimera from mouse

产品编号:3081181
规格:>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
包装规格:200 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3081181200 μG7940
产品别名

Ephrin-A1/Fc Chimera from mouse

B61

EFL-1

LERK-1

基本信息
MDL number
MFCD01867530
NACRES
NA.32
Biochem/physiol Actions【生化/生理作用】
EphA1 (ephrin receptor A1) plays an essential role in development, and is involved in the guidance of axonal and cell migration in nervous system. Disruption of ephrin signaling might be involved in the tumorigenesis of clear cell renal cell carcinoma, and absence of EphA1 has a favorable prognosis in the same. It might also be involved in the tumorigenesis and progression of prostate cancer, and might have potential as a marker for prognosis, as well as a therapeutic target. Studies show that it reduces the risk of Alzheimer′s disease, by hindering pathological changes in brain areas such as, hippocampus, lateral occipitotemporal and inferior temporal gyri. In esophageal squamous cells, it acts as differentiation marker. Its expression is elevated in esophageal squamous cell carcinoma, and this relates to advanced stage and metastasis to lymph node.
Member of ephrin ligand family that binds Eph receptor tyrosine kinases (EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7 and EphB1). Involved in pattern formation and morphogenesis. Ephrin-A1 can be detected on fetal osteoblasts, odotoblasts, chondrocytes, and squamous epithelium. Ephrin-A1 is expressed during embryonic vasculogenesis and during tumor-induced angiogenesis.
Other Notes【其他说明】
Extracellular domain of mouse ephrin-A1 (amino acids 1-182) fused to the C-terminal 6X histidine-tagged Fc region of human IgG.
Physical form【外形】
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Analysis Note【分析说明】
The biological activity is measured by its ability to bind recombinant mouse EphA2/Fc in ELISA.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
recombinant【重组】
expressed in NSO cells
Assay【测定】
>90% (SDS-PAGE)
form【形式】
lyophilized powder
potency【效能】
0.16-10 ng/mL
mol wt【分子量】
monomer calculated mol wt 46.8 kDa
50-55 kDa by SDS-PAGE (reducing)
packaging【包装】
pkg of 200 μg
storage condition【储存条件】
avoid repeated freeze/thaw cycles
impurities【杂质】
endotoxin, tested
UniProt accession no.【UniProt登记号】
P20827
storage temp.【储存温度】
−20℃
Gene Information
mouse ... Efna1(13636)
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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