非诺多泮 甲磺酸酯

C₁₆H₁₆ClNO₃ · CH₄O₃S

401.86

266-612-7

MFCD04112986

329825223

NA.77

Fenoldopam mesylate may be used to study dopamine D₁-mediated cell signaling.

Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.
Fenoldopam mesylate is a selective dopamine D₁ receptor agonist used as an antihypertensive agent. It is an agonist for D₁-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D₂-like receptors, α1 and α-adrenoceptors, 5HT₁ and 5HT₂ receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

100

≥98% (HPLC)

powder

desiccated

white to tan

271 ℃ (lit.)

DMSO: ≥15 mg/mL at ~60 ℃

room temp

CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23

1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)

CVKUMNRCIJMVAR-UHFFFAOYSA-N

human ... DRD1(1812)

10, 50 mg in glass bottle

GHS07

Warning

H302 - H317 - H319

P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

11 - Combustible Solids

WGK 3