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flt3-配体 来源于小鼠
flt3-Ligand from mouse
| 产品编号： | 3087792 |
| 规格： | recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
flt3-配体 来源于小鼠
flt3-Ligand from mouse
Fms-related tyrosine kinase 3 ligand
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | FMS-like tyrosine kinase 3 ligand (Flt3l), a cytokine, is also termed as Flk2/CD135. It is a hematopoietic growth factor. Recombinant murine Flt3-ligand is a soluble 18.6 kDa protein consisting of 163 amino acid residues. |
| Biochem/physiol Actions【生化/生理作用】 | Fms-like tyrosine kinase 3 (FLT3) ligand (FL), expressed by leukemic cells may help to increase the multiplication through an autocrine process. Flt3l (FMS-like tyrosine kinase 3 ligand) acts as a stimulant of hematopoietic progenitor cell proliferation. It facilitates the commitment of lymphoid lineage, and aids in dendritic cell (DC) development. It is involved in myoblast differentiation, and drives skeletal muscle regeneration. It acts on p120RasGAP (rat sarcoma GTPase activating protein) and suppresses Erk (extracellular signal-regulated kinase) signaling, which in turn promotes myogenesis. In lymphoid tissues, it modulates DC homeostasis, which is facilitated by steady state as well as proliferative T-cells. Recombinant murine Flt3-Ligand is a soluble 18.6 kDa protein consisting of 163 amino acid residues. |
| Sequence【序列】 | MTPDCYFSHS PISSNFKVKF RELTDHLLKD YPVTVAVNLQ DEKHCKALWS LFLAQRWIEQ LKTVAGSKMQ TLLEDVNTEI HFVTSCTFQP LPECLRFVQT NISHLLKDTC TQLLALKPCI GKACQNFSRC LEVQCQPDSS TLLPPRSPIA LEATELPEPR PRQ |
| Physical form【外形】 | Lyophilized from 10 mM Sodium Phosphate, pH 7.8. |
| Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃. |
产品性质
| biological source【生物来源】 | mouse |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥98% (HPLC) ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized |
| potency【效能】 | 5.0-8.0 ng/mL |
| mol wt【分子量】 | 18.6 kDa |
| packaging【包装】 | pkg of 10 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | <0.1 EU/μg endotoxin, tested |
| color【颜色】 | white to off-white |
| UniProt accession no.【UniProt登记号】 | P49772 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | mouse ... FLT3LG(14256) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
