FM19G11

C₂₃H₁₇N₃O₈

463.40

MFCD01174289

329799774

NA.77

FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):

• to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
• to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
• to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line

FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.

100

≥98% (HPLC)

powder

off-white to light brown

DMSO: ≥40 mg/mL

2-8℃

Cc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)c3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c2

1S/C23H17N3O8/c1-14-5-7-15(8-6-14)21(27)13-34-23(29)16-3-2-4-17(11-16)24-22(28)19-10-9-18(25(30)31)12-20(19)26(32)33/h2-12H,13H2,1H3,(H,24,28)

XVUOIWIIQVGWAJ-UHFFFAOYSA-N

5, 25 mg in glass bottle

11 - Combustible Solids

WGK 3