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GR 103691
产品别名
162408-66-4
GR 103691
4′-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1′-biphenyl]-4-carboxamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C30H35N3O3 |
| Molecular weight | 485.62 |
| MDL number | MFCD00936840 |
| PubChem Substance ID【PubChem化学物质编号】 | 24724488 |
| NACRES | NA.77 |
| Application【应用】 | GR 103691 has been used as a D3 receptor antagonist to test its:
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| Biochem/physiol Actions【生化/生理作用】 | GR 103691 increases the monosynaptic “stretch” reflex (MSR) amplitude in mice by its potent D3 receptor antagonist functionality. It inhibits the PD 128,907 mediated γ-aminobutyric acid (GABA) release. D3 dopamine receptor antagonist. |
| Features and Benefits【特点和优势】 | This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
| Legal Information【法律信息】 | Sold for research purposes under agreement from GlaxoSmithKline |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: soluble >5 mg/mL at 60 ℃ |
| originator【创始人】 | GlaxoSmithKline |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | COc1ccccc1N2CCN(CCCCNC(=O)c3ccc(cc3)-c4ccc(cc4)C(C)=O)CC2 |
| InChI | 1S/C30H35N3O3/c1-23(34)24-9-11-25(12-10-24)26-13-15-27(16-14-26)30(35)31-17-5-6-18-32-19-21-33(22-20-32)28-7-3-4-8-29(28)36-2/h3-4,7-16H,5-6,17-22H2,1-2H3,(H,31,35) |
| InChI key | JARNORYOPMINDY-UHFFFAOYSA-N |
| Gene Information | rat ... Htr1a(24473) |
| packaging【包装】 | 10 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
