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GR 64349
产品别名
137593-52-3
GR 64349
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C42H68N10O11S |
| Molecular weight | 921.11 |
| PubChem Substance ID【PubChem化学物质编号】 | 329799740 |
| NACRES | NA.32 |
| Amino Acid Sequence | Lys-Asp-Ser-Phe-Val-Gly-R-γ-lactam-Leu-Met-NH2 |
| General description【一般描述】 | Neurokinin (NK) receptors are acted upon by tachykinins or neurokinins namely, NKA and NKB. These are endogenous ligands. An exogenous agonist/ligand for NK2 is GR 64349 peptide. |
| Biochem/physiol Actions【生化/生理作用】 | GR 64349 peptide acts as an agonist of neurokinin (NK2) receptor, which leads to reduced NK2 response to kainate and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), but not to NMDA (N-methyl-D-aspartate). |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | >96% |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O |
| InChI | 1S/C42H68N10O11S/c1-23(2)19-32(40(61)46-27(35(45)56)15-18-64-5)52-17-14-28(42(52)63)47-41(62)34(24(3)4)51-38(59)29(20-25-11-7-6-8-12-25)49-39(60)31(22-53)50-37(58)30(21-33(54)55)48-36(57)26(44)13-9-10-16-43/h6-8,11-12,23-24,26-32,34,53H,9-10,13-22,43-44H2,1-5H3,(H2,45,56)(H,46,61)(H,47,62)(H,48,57)(H,49,60)(H,50,58)(H,51,59)(H,54,55)/t26-,27-,28-,29-,30-,31-,32-,34-/m0/s1 |
| InChI key | HVUNRXRFMQDMBO-NOJSRKIXSA-N |
| Gene Information | human ... TACR2(6865) mouse ... TACR2(21337) rat ... TACR2(25007) |
| packaging【包装】 | 1 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
