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GSK0660
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3094038 | 5 MG | 2120 |
产品别名
1014691-61-2
GSK0660
3-(((2-Methoxy-4-(phenylamino)phenyl)amino]sulfonyl)-2-thiophenecarboxylic acid methyl ester
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H18N2O5S2 |
| Molecular weight | 418.49 |
| MDL number | MFCD12828770 |
| PubChem Substance ID【PubChem化学物质编号】 | 329799945 |
| NACRES | NA.77 |
| General description【一般描述】 | GSK0660 has antiangiogenic property in oxygen-induced retinopathy. It also regulates tumor necrosis factor-α (TNFα)-induced inflammation in human retinal microvascular endothelial cells (HRMECs). |
| Application【应用】 | GSK0660 has been used to study the effects of bezafibrate (BZA) on hypertrophy. |
| Biochem/physiol Actions【生化/生理作用】 | GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8 (160 nM). GSK0660 is nearly inactive on PPARα and PPARγ with IC50s greater than 10 μM. |
| Features and Benefits【特点和优势】 | This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 10 mg/mL, clear |
| originator【创始人】 | GlaxoSmithKline |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | COC(=O)c1sccc1S(=O)(=O)Nc2ccc(Nc3ccccc3)cc2OC |
| InChI | 1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3 |
| InChI key | NDFKBGWLUHKMFY-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 2 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
