您的位置：首页 > 产品中心 > 192065-56-8， GYKI 52466 hydrochloride
GYKI 52466 hydrochloride
产品别名
192065-56-8
GYKI 52466 hydrochloride
1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H15N3O2 · HCl |
| Molecular weight | 329.78 |
| MDL number | MFCD00153803 |
| PubChem Substance ID【PubChem化学物质编号】 | 24277984 |
| NACRES | NA.77 |
| Application【应用】 | GYKI 52466 hydrochloride has been used as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor selective antagonist in cell viability assays to evaluate the specificity of kainate (KA) effect on cerebellar granule cells (CGCs). It has also been used as an AMPA blocker to study the function of glutamate in neuroadapted sindbis virus (NSV) -induced motor neuron death. |
| Biochem/physiol Actions【生化/生理作用】 | GYKI 52466 serves as an antagonist of several processes, mediated by glutamate. Selective allosteric AMPA receptor antagonist; anticonvulsant; skeletal muscle relaxant. |
| Features and Benefits【特点和优势】 | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
| Legal Information【法律信息】 | Sold under exclusive license from the Institute for Drug Research Ltd., Budapest, Hungary. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 0.39 mg/mL ethanol: 0.4 mg/mL 0.1 M HCl: 0.68 mg/mL methanol: 1 mg/mL H2O: >10 mg/mL |
| SMILES string | Cl[H].CC1=NN=C(c2ccc(N)cc2)c3cc4OCOc4cc3C1 |
| InChI | 1S/C17H15N3O2.ClH/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11;/h2-5,7-8H,6,9,18H2,1H3;1H |
| InChI key | RUBSCPARMVJNKX-UHFFFAOYSA-N |
| Gene Information | human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893) |
| packaging【包装】 | 10, 25, 100 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
