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HAMNO
产品别名
138736-73-9
HAMNO
(1Z)-1-[(2-Hydroxyanilino)methylidene]naphthalen-2-one
NS C111847
1-[[(2-Hydroxyphenyl)imino]methyl]-2-naphthalenol
NSC111847
CID 6335338
MLS000737724
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H13NO2 |
| Molecular weight | 263.29 |
| Biochem/physiol Actions【生化/生理作用】 | HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. HAMNO binds the N-terminal domain of RPA70 and inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR. HAMNO enhances DNA replication stress in cancer cells and slow tumor growth in vivo. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | yellow to orange |
| solubility【溶解性】 | DMSO: 10 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
