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Hexamethonium chloride
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3096382 | 5 G | 530 | |||
| 3096382 | 25 G | 1390 |
产品别名
60-25-3
Hexamethonium chloride
Hexamethonium dichloride
N,N,N,N′,N′,N′-Hexamethyl-1,6-hexanediaminium dichloride
N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dichloride
基本信息
| Linear Formula【线性分子式】 | (CH3)3N(Cl)(CH2)6N(Cl)(CH3)3 |
| Molecular weight | 273.29 |
| Beilstein | 3714806 |
| EC number【EC 号】 | 200-465-1 |
| MDL number | MFCD00031563 |
| PubChem Substance ID【PubChem化学物质编号】 | 24277842 |
| NACRES | NA.77 |
| General description【一般描述】 | Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction. |
| Application【应用】 | Hexamethonium chloride has been used to block the responses of nicotinic receptors towards it agonists. It has also been used to study the mechanosensitivity of viscerofugal neurons. |
| Biochem/physiol Actions【生化/生理作用】 | Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognitive impairment. nAChR antagonist is used to study the effect of loss of receptor function. Hexamethonium has a peripheral action over blocking the nAChR. |
产品性质
| form【形式】 | solid (hygroscopic) |
| color【颜色】 | white |
| solubility【溶解性】 | H2O: soluble ethanol: soluble |
| SMILES string | [Cl-].[Cl-].C[N+](C)(C)CCCCCC[N+](C)(C)C |
| InChI | 1S/C12H30N2.2ClH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2 |
| InChI key | PYIHTIJNCRKDBV-UHFFFAOYSA-L |
| Gene Information | human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143) |
| packaging【包装】 | 5, 25 g in poly bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
