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JNJ-40418677
产品别名
1146594-87-7
JNJ-40418677
2-(S)-(3,5-Bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H22F6O2 |
| Molecular weight | 480.44 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC50 = 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity. In vivo experiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 15 mg/mL, clear |
| originator【创始人】 | Johnson & Johnson |
| relevant disease(s)【相关疾病】 | Alzheimer′s disease |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H300 - H413 |
| Precautionary Statements | P264 - P270 - P273 - P301 + P310 - P405 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 2 Oral - Aquatic Chronic 4 |
| Storage Class Code【储存分类代码】 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
