您的位置：首页 > 产品中心 > 925701-49-1， KU-60019
KU-60019
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3103025 | 5 MG | 1530 | |||
| 3103025 | 25 MG | 5620 |
产品别名
925701-49-1
KU-60019
(2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C30H33N3O5S |
| Molecular weight | 547.67 |
| MDL number | MFCD19690944 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825862 |
| NACRES | NA.77 |
| Application【应用】 | KU-60019 has been used to block ataxia telangiectasia mutated (ATM), to study its association of with the regulation of H2AX (H2A histone family, member X) and apoptosis inducing factor (AIF)-mediated cell death. |
| Biochem/physiol Actions【生化/生理作用】 | KU-60019 is a potent inhitor of ATM (ataxia telangiectasia mutated) kinase, a member of phosphatidylinositol-3-kinase-related kinase family that is critical in regulating cell cycle checkpoints and DNA repair. KU-60019 has an IC50 value of 6.3 nM. KU-60019 radiosensitizes U1242 human glioma cells, and also blocks U1242 cell migration and invasion through matrigel. |
| Other Notes【其他说明】 | KU-60019 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the KU-60019 probe summary on the Chemical Probes Portal website. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O=C(CN1C[C@H](C)O[C@H](C)C1)NC(C=C2)=CC3=C2SC4=C(C5=CC(C=C(N6CCOCC6)O5)=O)C=CC=C4C3 |
| InChI | 1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+ |
| InChI key | SCELLOWTHJGVIC-BGYRXZFFSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
