您的位置：首页 > 产品中心 > 15985-39-4， L -蛋氨酸亚砜酰亚胺
L -蛋氨酸亚砜酰亚胺
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3103639 | 250 MG | 1780 | |||
| 3103639 | 500 MG | 2860 | |||
| 3103639 | 1 G | 3860 | |||
| 3103639 | 5 G | 13340 |
产品别名
15985-39-4
结构式
基本信息
| Linear Formula【线性分子式】 | CH3S(O)(=NH)CH2CH2CH(NH2)CO2H |
| Molecular weight | 180.23 |
| Beilstein | 6175446 |
| MDL number | MFCD00002621 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278555 |
| NACRES | NA.32 |
| Application【应用】 | L-甲硫氨酸亚砜亚胺已被用作谷氨酰胺合成酶(GS)活性的一种有效抑制剂。 |
| Biochem/physiol Actions【生化/生理作用】 | As a potent inhibitor of glutamine synthetase activity (GS), this reagent has widely been used as a selection agent for plasmid integration in Chinese hamster ovary (CHO) and other mammalian cell lines. The growing demand for high yield cell banks for production of recombinant proteins for therapeutics has resulted in two major systems for selection of stable and active clones, Methotrexate selection of dihydrofolate reductase (DHFR) overexpressing cells and MSX selection of glutamine synthetase overexpressing cells. Cells are grown in the absence of glutamine in the media and inhibition of the endogenous activity of glutamine synthetase results in cell death for cells lacking overexpression. The MSX-glutamine synthetase selection mechanism provides benefits over that of the Methotrexate-DHFR system in that it typically requires a single amplification step and results in significant reduction of time to produce high stability, highly amplified clones. L-Methionine sulfoximine (MSX) enhances NH3 production in seedling leaves wheat, barley, corn and sorghum plants by inhibiting GS activity. MSX increases ornithine decarboxylase activity and decreases the survival rate in a model of transient cerebral ischemia. |
产品性质
| Quality Level【质量水平】 | 300 |
| mp | >210 ℃ (dec.) (lit.) |
| SMILES string | CS(=N)(=O)CC[C@H](N)C(O)=O |
| InChI | 1S/C5H12N2O3S/c1-11(7,10)3-2-4(6)5(8)9/h4,7H,2-3,6H2,1H3,(H,8,9)/t4-,11?/m0/s1 |
| InChI key | SXTAYKAGBXMACB-DPVSGNNYSA-N |
| packaging【包装】 | 250, 500 mg in poly bottle 1, 5 g in poly bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
