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L-655,708
| 产品编号： | 3103900 |
| 规格： | ≥98% (HPLC), powder |
| CAS NO： | 130477-52-0 |
| 包装规格： | 5 MG，25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
130477-52-0
L-655,708
L-655708
Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H19N3O4 |
| Molecular weight | 341.36 |
| MDL number | MFCD02684528 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278527 |
| NACRES | NA.77 |
| Application【应用】 | L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner. |
| Biochem/physiol Actions【生化/生理作用】 | L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats. Novel ligand selective for the benzodiazepine site of GABAA receptors which contain the α5 subunit. |
| Features and Benefits【特点和优势】 | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| solubility【溶解性】 | DMSO: ≥6.0 mg/mL (Warmed) H2O: insoluble |
| originator【创始人】 | Merck & Co., Inc., Kenilworth, NJ, U.S. |
| SMILES string | CCOC(=O)c1ncn2-c3ccc(OC)cc3C(=O)N4CCCC4c12 |
| InChI | 1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1 |
| InChI key | YKYOQIXTECBVBB-AWEZNQCLSA-N |
| Gene Information | human ... GABRA5(2558) |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
