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来曲唑
Letrozole
| 产品编号： | 3105279 |
| 规格： | Pharmaceutical Secondary Standard; Certified Reference Material |
| CAS NO： | 112809-51-5 |
| 包装规格： | 1 G |
| 产品类别： | 进口试剂 |
| 品牌： | Supelco |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3105279 | 1 G | 1750 |
产品别名
112809-51-5
来曲唑
Letrozole
4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
4,4′-(1H-1,2,4-三唑-1-基亚甲基)双苄腈
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H11N5 |
| Molecular weight | 285.30 |
| MDL number | MFCD00866241 |
| PubChem Substance ID【PubChem化学物质编号】 | 329823451 |
| NACRES | NA.24 |
| General description【一般描述】 | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Letrozole is used for the treatment of breast cancer in hormone-dependent postmenopausal patients. The drug works by blocking the synthesis of estrogen, a causative agent for cancer. |
| Application【应用】 | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Letrozole may be used as a pharmaceutical reference standard for the determination of the analyte in biological/environmental samples and pharmaceutical formulations by various chromatography techniques. |
| Biochem/physiol Actions【生化/生理作用】 | 来曲唑是第三代非甾体芳香酶抑制剂。 它是芳香酶系统的竞争性抑制剂，因此可抑制雄激素向雌激素转化。来曲唑通过竞争性结合到该酶的细胞色素P450亚基的血红素上而抑制芳香酶，导致所有组织中雌激素的生物合成减少。 |
| Analysis Note【分析说明】 | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Other Notes【其他说明】 | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Footnote【附注】 | To see an example of a Certificate of Analysis for this material enter LRAA4186 in the slot below. This is an example certificate only and may not be the lot that you receive. |
产品性质
| Quality Level【质量水平】 | 300 |
| grade【等级】 | certified reference material pharmaceutical secondary standard |
| CofA | current certificate can be downloaded |
| packaging【包装】 | pkg of 1 g |
| technique(s) | HPLC: suitable gas chromatography (GC): suitable |
| application(s) | pharmaceutical (small molecule) |
| format【格式】 | neat |
| pharmacopeia traceability【药典可追溯性】 | traceable to PhEur Y0000685 traceable to USP 1356971 |
| storage temp.【储存温度】 | 2-30℃ |
| SMILES string | N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3 |
| InChI | 1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H |
| InChI key | HPJKCIUCZWXJDR-UHFFFAOYSA-N |
| Gene Information | human ... CYP19A1(1588) |
安全信息
| Pictograms【象形图】 | GHS08 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H361fd - H373 |
| Precautionary Statements | P202 - P260 - P280 - P308 + P313 - P405 - P501 |
| Hazard Classifications【危险分类】 | Repr. 2 - STOT RE 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
