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Lixivaptan
产品别名
168079-32-1
Lixivaptan
WAY-VPA 985
N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide
VPA 985
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H21ClFN3O2 |
| Molecular weight | 473.93 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Arginine vasopressin (AVP) plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). Lixivaptan is an AVP V2-receptor selective antagonist that increases water excretion and normalizes serum sodium levels. Lixivaptan has been in clinical trials for hyponatremia associated with heart failure. |
产品性质
| Quality Level【质量水平】 | 100 |
| description【描述】 | 4% w/w in ethyl acetate |
| Assay【测定】 | ≥96% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | room temp |
| InChI | 1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33) |
| InChI key | PPHTXRNHTVLQED-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
