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MBX-102
产品别名
24136-23-0
MBX-102
JNJ39659100
(aR)-4-Chloro-a-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
Arhalofenate
MBX-102/JNJ39659100
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H17ClF3NO4 |
| Molecular weight | 415.79 |
| NACRES | NA.77 |
| Application【应用】 | MBX-102 may be used in PPAR-mediated cell signaling studies. |
| Biochem/physiol Actions【生化/生理作用】 | MBX-102 has a potent transrepression effect on PPARγ. It is an oral glucose-reducing agent and also has insulin-sensitizing properties. It is useful as treatment for type 2 diabetes. MBX-102 also lowers triglycerides in a PPARα-independent manner. MBX-102 is a selective PPAR modulator (SPPARM) and has been shown to inhibit phosphorylation of PPARγ. MBX-102 is converted to the active form, MBX-102 acid, in vivo. |
| Features and Benefits【特点和优势】 | This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to tan |
| solubility【溶解性】 | DMSO: ≥35 mg/mL |
| originator【创始人】 | Johnson & Johnson |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06,GHS09 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 - H319 - H400 |
| Precautionary Statements | P273 - P301 + P310 + P330 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 |
| Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
