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MC2050 hydrate
产品别名
MC2050 hydrate
2-[2-(4-(2-pyridyl)-1-piperazinyl)ethylsulfanyl]-3H-quinazolin-4-one dihydrochloride hydrate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H21N5OS·2HCl · xH2O |
| Molecular weight | 440.39 (anhydrous basis) |
| MDL number | MFCD21608523 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825234 |
| NACRES | NA.77 |
| Application【应用】 | MC2050 hydrate may be used in cell signaling studies. |
| Biochem/physiol Actions【生化/生理作用】 | MC2050 is a water-soluble PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells. |
| Features and Benefits【特点和优势】 | This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: ≥5 mg/mL at warmed to 60 ℃ |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O.Cl.Cl.O=C1NC(SCCN2CCN(CC2)c3ccccn3)=Nc4ccccc14 |
| InChI | 1S/C19H21N5OS.2ClH.H2O/c25-18-15-5-1-2-6-16(15)21-19(22-18)26-14-13-23-9-11-24(12-10-23)17-7-3-4-8-20-17;;;/h1-8H,9-14H2,(H,21,22,25);2*1H;1H2 |
| InChI key | LMZZPRHHBPFDGE-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
