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MCOPPB trihydrochloride hydrate
产品别名
1028969-49-4
MCOPPB trihydrochloride hydrate
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole trihydrochloride hydrate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H40N4 · 3 HCl · xH2O |
| Molecular weight | 518.01 (anhydrous basis) |
| PubChem Substance ID【PubChem化学物质编号】 | 329823741 |
| Biochem/physiol Actions【生化/生理作用】 | MCOPPB trihydrochloride is a potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. MCOPPB is the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis. |
| Features and Benefits【特点和优势】 | This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
| Other Notes【其他说明】 | This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
| Legal Information【法律信息】 | Sold for research purposes under agreement from Pfizer Inc. Pfizer is a registered trademark of Pfizer, Inc. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | >98% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Pfizer® |
| color【颜色】 | white to tan |
| solubility【溶解性】 | H2O: ≥13 mg/mL |
| originator【创始人】 | Pfizer |
| storage temp.【储存温度】 | room temp |
| SMILES string | O.Cl.Cl.Cl.CC1(CCCCCCC1)N2CCC(CC2)n3c(nc4ccccc34)[C@@H]5CCCNC5 |
| InChI | 1S/C26H40N4.3ClH.H2O/c1-26(15-7-3-2-4-8-16-26)29-18-13-22(14-19-29)30-24-12-6-5-11-23(24)28-25(30)21-10-9-17-27-20-21;;;;/h5-6,11-12,21-22,27H,2-4,7-10,13-20H2,1H3;3*1H;1H2 |
| InChI key | UQBVSGBDJOJHIP-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
