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Merbarone
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3108790 | 25 MG | 1660 |
产品别名
97534-21-9
Merbarone
5-(N-Phenylcarbamoyl)-2-thiobarbituric acid
NSC-336628
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C11H9N3O3S |
| Molecular weight | 263.27 |
| MDL number | MFCD00866337 |
| PubChem Substance ID【PubChem化学物质编号】 | 24724534 |
| Application【应用】 | Merbarone has been used to study its effect on the occurrence of DNA lesions. |
| Biochem/physiol Actions【生化/生理作用】 | Thiobarbituric acid with aniline joined by an amide linkage forms merbarone. It is known to prolong cell cycle progression by inducing DNA double strand breaks, retarding S phase and arresting G2 phase. This delays cell entry into mitosis. Merbarone possesses cytotoxic and genotoxic action and promotes endoreduplication. Merbarone has mild antitumor action and is also found to nephrotoxic. Selective topoisomerase II inhibitor. Blocks topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. Induces apoptosis in CEM cells via caspase 3 dependent mechanism. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| drug control | regulated under CDSA - not available from sigma-aldrich Canada |
| solubility【溶解性】 | DMSO: >5 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1NC(=S)NC(=O)C1C(=O)Nc2ccccc2 |
| InChI | 1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18) |
| InChI key | JARCFMKMOFFIGZ-UHFFFAOYSA-N |
| packaging【包装】 | 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
