Methyl-3,4-dephostatin

C₇H₈N₂O₃

168.15

MFCD01076450

24278575

NA.77

Methyl-3,4-dephostatin has been used as:

• an inhibitor for methyltransferases
• a kinase-related inhibitor for human transglutaminase
• a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein

Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).
Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases.

100

>98% (HPLC)

powder

red-brown

DMSO: soluble 18 mg/mL
H₂O: insoluble

2-8℃

CN(N=O)c1ccc(O)c(O)c1

1S/C7H8N2O3/c1-9(8-12)5-2-3-6(10)7(11)4-5/h2-4,10-11H,1H3

XAKAQCMEMMZUEO-UHFFFAOYSA-N

human ... PTPN1(5770)

11 - Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)