2'-脱氧尿苷 5'-单磷酸 二钠盐

C₉H₁₁N₂O₈PNa₂

352.15

255-687-1

MFCD00065282

24893787

NA.51

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).

2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.
2′-Deoxyuridine 5′-monophosphate disodium salt has been used:

• in ultraperformance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) assay
• to stimulate proliferation of peripheral blood mononuclear cell (PBMCs) exposed to influenza virus antigen
• in thymidylate synthase activity assay Helicobacter pylori

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

200

Sigma Grade

−20℃

[Na].OC1CC(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O

1S/C9H13N2O8P.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17);;

WXIVKKBDJOCRNB-UHFFFAOYSA-N

100, 250 mg in poly bottle
1 g in poly bottle

GHS07

Warning

H302 - H315 - H319 - H335

P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Respiratory system

11 - Combustible Solids

WGK 3

dust mask type N95 (US), Eyeshields, Gloves