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MK-0343
产品别名
233275-76-8
MK-0343
7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
MRK-409
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H17F2N7O |
| Molecular weight | 397.38 |
| MDL number | MFCD22683821 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825556 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | MK-0343 (MRK-409) is a partial agonist for GABAA receptors with comparable Ki values for α1, α2, α3 and α5 containing receptors (0.2 – 0.4 nM). The compound has the greatest agonist activity against α3 receptors, and is brain penatrant, and displays anxiolytic activity in rodent and primate models. |
| Features and Benefits【特点和优势】 | This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 10 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cn1ncnc1COc2nn3c(nnc3cc2C4CCC4)-c5c(F)cccc5F |
| InChI | 1S/C19H17F2N7O/c1-27-16(22-10-23-27)9-29-19-12(11-4-2-5-11)8-15-24-25-18(28(15)26-19)17-13(20)6-3-7-14(17)21/h3,6-8,10-11H,2,4-5,9H2,1H3 |
| InChI key | GOIFCXRIFSYPFG-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
