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ML167
产品别名
1285702-20-6
ML167
5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol
NCGC00188654
CID 44968231
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H17N3O3 |
| Molecular weight | 335.36 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B, and minimal activity against a panel of other kinases tested. The Cdc2-like kinases (Clk′s) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk′s) are involved in regulation of gene splicing. The Cdc2-like kinases phosphorylate the serine/arginine-rich (SR) proteins, a major component of the spliceosome. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | off-white to gray-brown |
| solubility【溶解性】 | DMSO: 10 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
