(2-羟丙基)-γ-环糊精

NA.22

(2-Hydroxypropyl)-γ-cyclodextrin belongs to the class of cyclodextrin derivatives, which exhibit a greater extent of solubility in water compared to their parent compounds. It is widely used in parenteral formulations and solid dosage forms to aid in the improvement of their stability, dissolution, bioavailability, etc.

(2-Hydroxypropyl)-γ-cyclodextrin may be used:

• As a mobile phase additive in the study of the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase-high performance liquid chromatography (RP-HPLC) technique.
• As a chiral surfactant for the analysis of econazole by micellar electrokinetic chromatography (MEKC).
• As an analytical standard for the determination of the analyte in biological samples by HPLC.
• As a chiral selector for the identification of propiconazole by MEKC.

[α]20/D +145°, c = 1 in H₂O

100

average M_w ~1,580

0.6 molar substitution

1S/C51H88O38/c1-14(56)8-73-11-21-42-29(64)36(71)50(81-21)85-40-19(6-54)79-48(34(69)27(40)62)89-44-23(13-75-10-16(3)58)82-51(37(72)30(44)65)86-41-20(7-55)78-47(33(68)26(41)61)88-43-22(12-74-9-15(2)57)80-49(35(70)28(43)63)84-39-18(5-53)76-45(31(66)24(39)59)83-38-17(4-52)77-46(87-42)32(67)25(38)60/h14-72H,4-13H2,1-3H3/t14?,15?,16?,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1

ODLHGICHYURWBS-RYJYQAAZSA-N

5, 25 g in glass bottle

11 - Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)