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2,4,3′,5′-四甲氧基二苯乙烯
2,4,3′,5′-tetramethoxystilbene
产品别名
24144-92-1
2,4,3′,5′-四甲氧基二苯乙烯
2,4,3′,5′-tetramethoxystilbene
1-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy-benzene
2,3′,4,5′-Tetramethoxystilbene
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C18H20O4 |
Molecular weight | 300.35 |
MDL number | MFCD03428621 |
PubChem Substance ID【PubChem化学物质编号】 | 329824983 |
NACRES | NA.79 |
Biochem/physiol Actions【生化/生理作用】 | 2,3′,4,5′-Tetramethoxystilbene, also known as TMS, is a selective and competitive inhibitor of cytochrome P450 1B. It is a synthetic trans-stilbene analog. TMS is an analog of resveratrol and is an anti-cancer agent. TMS is cytotoxic to gefitinib-resistant (G-R) non-small-cell lung cancer (NSCLC) cells. It binds to sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and promotes apoptosis and autophagy. TMS is also a selective inhibitor of CYP1B1. |
产品性质
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | powder |
technique(s) | HPLC: suitable |
color【颜色】 | white to yellow |
storage temp.【储存温度】 | −20℃ |
SMILES string | COC1=CC(OC)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2 |
InChI | 1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+ |
InChI key | JDBCWSHYEQUBLW-AATRIKPKSA-N |
packaging【包装】 | 10 mg in glass bottle 50 mg in poly bottle |
安全信息
Pictograms【象形图】 | GHS07 |
Signal word【警示用语:】 | Warning |
Hazard Statements | H302 |
Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
WGK | WGK 3 |