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Anti-ADAR2 antibody, Mouse monoclonal
产品编号: | 3140616 |
规格: | clone ADAR2-8, purified from hybridoma cell culture |
包装规格: | 200 μL |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-ADAR2 antibody, Mouse monoclonal
Anti-ADARB1
Anti-DRADA2
Anti-DRABA2
Anti-RED1
Anti-RNA Editase 1
Anti-Adenosine Deaminase, RNA-specific B1
Anti-RNA-editing enzyme 1
基本信息
MDL number | MFCD02686608 |
NACRES | NA.41 |
General description【一般描述】 | Adenosine deaminase acting on RNA type 2 (ADAR2) is localized predominantly in the nucleus. Adenosine deaminase acting on RNA type 2 (ADAR2), also known as adenosine deaminase, RNA specific B1 (ADARB1), is encoded by the gene mapped to human chromosome 21q22.3. ADARB1 is characterized with two double-stranded RNA-binding domains and a deaminase domain involved in editing action. |
Application【应用】 | Monoclonal Anti-ADAR2 antibody produced in mouse has been used in immunoblotting. |
Biochem/physiol Actions【生化/生理作用】 | Adenosine deaminase acting on RNA type 2 (ADAR2) enzyme plays a vital role in editing pre-mRNA of glutamate receptor B subunit. Combined effect of ADAR2 and HTR2C (5-hydroxytryptamine receptor 2C) variants contribute to the suicide attempt (SA) vulnerability in psychiatric patients. ADAR2 is a candidate gene for neurological diseases, such as bipolar affective disorder and epilepsy. Decrease in the activity of ADAR2 enzyme results in Adenosine deaminase acting on RNA type 2 (ADAR2) activity is directly involved in both cell cycle by slowing down cell growth rate at the S-G2 phase and in cell migration. Decrease in ADAR2 editing activity is linked to tumor malignancy (astrocytoma grade I-IV) in children. |
Physical form【外形】 | Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide. |
产品性质
biological source【生物来源】 | mouse |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | purified from hybridoma cell culture |
antibody product type | primary antibodies |
clone【克隆】 | ADAR2-8, monoclonal |
mol wt【分子量】 | antigen ~81 kDa |
species reactivity | human |
packaging【包装】 | antibody small pack of 25 μL |
concentration【浓度】 | ~1 mg/mL |
technique(s) | western blot: 1-2 μg/mL using HL-60 total cell extract |
UniProt accession no.【UniProt登记号】 | P78563 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... ADARB1(104) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |