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Anti-ARP2 antibody, Mouse monoclonal
| 产品编号： | 3141203 |
| 规格： | clone FMS96, purified from hybridoma cell culture |
| 包装规格： | 25 μL，200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD03097266 |
| NACRES | NA.41 |
| General description【一般描述】 | Mouse Monoclonal Anti-ARP2 antibody binds to human, canine, rat, and mouse ARP2, 40-45kDa. Anti-ARP2 antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the FMS96 hybridoma produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with recombinant human ARP2. ARP2 is part of a complex with 7 subunits called ARP2/3. ARP2 is an actin-related protein that function to regulate the actin cytoskeleton. |
| Immunogen【免疫原】 | recombinant human ARP2 |
| Application【应用】 | Anti-ARP2 antibody, Mouse monoclonal has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | Actin-related protein 2 (ARP2) is a part of ARP2/3 complex and play a key role in actin filament formation. It mediates changes in the polymerization state of actin filaments. The Wiskott-Aldrich Syndrome protein (WASP) regulates ARP2/3 complex of proteins. The ARP2/3 complex and its activator spinocerebellar ataxia, autosomal recessive 2 (Scar2) are involved in Golgi polarization in NIH 3T3 cells. However in primary astrocytes, Golgi polarization involves neither actin cytoskeleton or Arp2/3 complex nor any WASP-family of proteins. In a different model, it was found that the ARP2/3 complex was necessary for neutrophil chemotaxis and phagocytosis. By genetic and loss of function studies, it was demonstrated that Scar is the major regulator of the ARP2/3 complex rather than the WASP family of proteins, the latter having more restricted roles in specific cellular events. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | FMS96, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 40-45 kDa |
| species reactivity | rat, human, mouse, canine |
| packaging【包装】 | antibody small pack of 25 μL |
| technique(s) | immunocytochemistry indirect ELISA: suitable microarray: suitable western blot: 0.5-1 μg/mL using total cell extract of C2 mouse myoblast cells |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | P61160 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ACTR2(10097) mouse ... Actr2(66713) rat ... Actr2(289820) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
