Monoclonal Anti-BRCA1 antibody produced in mouse

NA.41

Protein fragment expressed in E. coli corresponding to amino acids 762-1315.

For ICC/IF: Use at a concentration of 1 μg/mL. For WB: 1:500-1:3000. For IHC-P: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the researcher

BRCA1-17F8 recognizes full-length BRCA1, a 220kDa nuclear phosphoprotein, and does not recognize the Aexon 11 splice variant. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Its usefulness to monitor functional inactivation of BRCA1 in sporadic breast cancers is under active investigation.

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Phosphate-buffered saline, no preservative added.

mouse

unconjugated

purified immunoglobulin

primary antibodies

17F8
monoclonal

liquid

220 kDa

human, mouse

1 mg/mL

ChIP: suitable
ELISA: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

IgG1

P38398

wet ice

−20℃

human ... BRCA1(672)

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids