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Monoclonal Anti-Cathepsin K 小鼠抗

Monoclonal Anti-Cathepsin K antibody produced in mouse
产品编号:3142177
规格:~2 mg/mL, clone CL124-1H6, purified immunoglobulin, buffered aqueous solution
包装规格:100 μL,200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3142177100 μL4570
3142177200 μL6000
产品别名

Monoclonal Anti-Cathepsin K 小鼠抗

Monoclonal Anti-Cathepsin K antibody produced in mouse

Anti-CTSK

Anti-CTSO2

Anti-PYCD

Anti-PKND

基本信息
MDL number
MFCD02097890
NACRES
NA.41
General description【一般描述】
Monoclonal Anti-Cathepsin K (mouse IgG2b isotype) is derived from the hybridoma CK124-1H6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with recombinant human cathepsin K.
Cathepsins are proteases that normally localized in lysosomes of almost all mammalian cells, but under certain conditions they can be secreted from the cell. Cathepsins are classified based on their functions and presence of active site such as cathepsin B, D, K, V, F etc.
Specificity【特异性】
The antibody does not cross react with the closely related lysosomal cysteine proteases cathepsins L, B, H, S, V and W.
Immunogen【免疫原】
recombinant human cathepsin K. The antibody epitope resides within the peptide sequence RGYREIPEGNEKAL that corresponds to amino acids 222-235.
Application【应用】
Monoclonal Anti-Cathepsin K antibody produced in mouse has been used in western blotting and enzyme linked immunosorbent assay (ELISA).
Biochem/physiol Actions【生化/生理作用】
Cathepsin is involved in various functions such as intracellular degradation of exogenous and endogenous proteins, activation of enzyme precursors, and tumor invasion and metastasis. Among all the types, cathepsins K (Ctsk) is highly expressed in osteoclasts that plays a crucial role in bone remodeling and resorption. Cathepsin K protein was found in primary breast carcinoma and prostate cancer where it performs in the invasive process of prostate cancers, thyroid carcinoma, lung adenocarcinoma and breast carcinoma. Its deficency causes pycnodysostosis, a rare bone dysplasia with an osteopetrotic-like phenotype.
Physical form【外形】
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
CL124-1H6, monoclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~27 kDa
species reactivity
human
concentration【浓度】
~2 mg/mL
technique(s)
indirect ELISA: suitable
western blot: 10-20 μg/mL using total cell extracts of HCT-116 cells
isotype【同位素/亚型】
IgG2b
UniProt accession no.【UniProt登记号】
P43235
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... CTSK(1513)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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