Monoclonal Anti-CD11b antibody produced in mouse

100

mouse

unconjugated

purified immunoglobulin

primary antibodies

MEM-174, monoclonal

buffered aqueous solution

human

1 mg/mL

flow cytometry: suitable

IgG2a

NM_000632.3

P11215

wet ice

2-8℃

human ... ITGAM(3684)

Cluster of differentiation 11b (CD11b), also known as integrin subunit α M (ITGAM), is encoded by the gene mapped to human chromosome 16p11.2.The encoded protein belongs to the integrin α chain family. CD11b is expressed by a variety of myeloid cell types, such as dendritic cells, macrophages, monocytes and neutrophils.
The antibody MEM-174 recognizes CD11b antigen (Mac-1 alpha), a 165-170 kDa type I transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells. The CD11b mediates neutrophil and monocyte interactions with stimulated endothelium.

Human granulocytes

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Cluster of differentiation 11b (CD11b) acts as a receptor for complement component C3 degradation product, iC3b. CD11b interacts with β2 chain (ITGB2) to form a leukocyte integrin (MAC-1 or complement receptor 3 (CR3)), which in turn plays a crucial role in adherence of neutrophils and monocytes to stimulated endothelium. Mutation in the gene increases the risk of susceptibility to systemic lupus erythematosus (SLE) and acute inflammatory demyelinating polyradiculoneuropathy (AIDP).

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Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids