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Monoclonal Anti-CD16-PE antibody produced in mouse
| 产品编号： | 3142422 |
| 规格： | clone MEM-154, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 100 TEST |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-CD16-PE antibody produced in mouse
Anti-FCGR3A
Anti-FcγRIII
基本信息
| NACRES | NA.44 |
| General description【一般描述】 | Cluster of differentiation 16 (CD16), also known as Fc fragment of IgG receptor IIIa (FCGR3A) gene, is localized to human chromosome 1 and codes for FC γ IIIa receptor (FcγRIIIa). The encoded protein is expressed on natural killer (NK) cells and macrophages. CD16 is a transmembrane protein characterized with a 21 amino acid cytoplasmic tail. The antibody MEM-154 reacts with the epitope on CD16 antigen that residing in proximity to FG loop (probably BC or C′E loop). CD16 is a low affinity receptor for aggregated IgG (FcgammaRIII antigen). The antibody MEM-154 reacts with CD16+ granulocytes. |
| Immunogen【免疫原】 | Human granulocytes |
| Application【应用】 | The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests. |
| Biochem/physiol Actions【生化/生理作用】 | Cluster of differentiation 16 (CD16) is one of the activating Fc receptors to which, the Fc region of immunoglobulin G (IgG) binds and mediates inflammatory responses such as antibody-dependent cell-mediated cytotoxicity (ADCC). Dimorphism in CD16 might influence the therapeutic response to rituximab, which is an anti-CD20 humanized immunoglobulin G1 extensively used in the treatment of non-hodgkin lymphomas. Mutation in the gene might lead to natural killer (NK) cell immunodeficiency. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | phycoerythrin (R-PE) conjugate |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | MEM-154, monoclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | flow cytometry: suitable |
| isotype【同位素/亚型】 | IgG1 |
| NCBI accession no.【NCBI登记号】 | NM_000569.6 |
| UniProt accession no.【UniProt登记号】 | P08637 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| Gene Information | human ... FCGR3A(2214) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
