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Monoclonal Anti-CD28 antibody produced in mouse
| 产品编号： | 3142557 |
| 规格： | clone CD28.2, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Cluster of differentiation 28 (CD 28) is a lymphocyte surface protein. In human chromosome, the gene CD28 is localized on 2q33.2. The antibody CD28.2 reacts with CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells. HLDA V.; WS Code 5T CD28.05. |
| Immunogen【免疫原】 | DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA |
| Biochem/physiol Actions【生化/生理作用】 | Cluster of differentiation 28 (CD28) acts as a costimulatory molecule for T cell activation and proliferation. CD28 might function as a tumor suppressor gene and the polymorphism is related to increased risk of breast cancer. CD28 plays a key role in allogenic responses. The level of CD28 is upregulated in CD4+ lymphocytes during acute graft rejection. Polymorphism in CD28 owing to higher frequency of CD28 molecule has impact on schizophrenia. Mutations in CD28 is associated with T cell lymphoma′s and neoplasm, leading to accelerated tumour growth. CD28 along with phosphatidylinositol 3 kinase (PI3K) regulates diverse biochemical pathways. CD28 signals to T cells and prevents anergy and apoptosis and promotes T cell proliferation and production of interleukin-2. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | CD28.2, monoclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human, nonhuman primates |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | FUNC: suitable flow cytometry: suitable immunoblotting: suitable immunocytochemistry: suitable immunohistochemistry: suitable immunoprecipitation (IP): suitable |
| isotype【同位素/亚型】 | IgG1 |
| NCBI accession no.【NCBI登记号】 | NM_001243077.1 |
| UniProt accession no.【UniProt登记号】 | P10747 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| Gene Information | human ... CD28(940) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
