抗-DC-SIGN1单克隆抗体 小鼠抗

MFCD03701938

NA.41

DC-SIGN is a type II protein C-type lectin that binds mannose-rich molecules such as ICAM-3 and ICAM-2 in a calcium dependent manner. DC-SIGN, a 44 kDa molecule, is identical to the HIV-1 binding protein.

Recognizes human DC-SIGN on transfected cells and on monocyte derived dentritic cells. The antibody does not react with either parental mouse cells or irrelevant transfectants, such as human DC-SIGN2.

purified from NIH/3T3 cells transfected with recombinant human DC-SIGN.

Monoclonal Anti-DC-SIGN1 antibody produced in mouse is suitable for flow cytometry, immunocytochemistry at a working concentration of 8-25 μg/mL, immunohistochemistry at 8-25 μg/mL using fixed cells and tissue sections and western blotting at 1 μg/mL.

DC-SIGN1 is involved in molecular interactions between dendritic cells and resting T-cells. DC-SIGN interacts with viruses such as X4, R5, X4R5 HIV-1 strains, HIV-2, and SIV. It captures HIV-1 through its interaction with the gp120 envelope glycoprotein and promotes efficient infection of CD4⁺ T cells that co-express chemokine receptors.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

200

mouse

unconjugated

purified immunoglobulin

primary antibodies

120507, monoclonal

lyophilized powder

human

flow cytometry: 2.5 μg using 10⁶ cells
immunocytochemistry: 8-25 μg/mL
immunohistochemistry: 8-25 μg/mL using fixed cells and tissue sections
western blot: 1 μg/mL

IgG2b

Q9NNX6

−20℃

human ... CD209(30835)

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

11 - Combustible Solids

WGK 1

Eyeshields, Gloves, type N95 (US)