Monoclonal Anti-Endothelin-1 antibody produced in mouse

MFCD00162279

NA.41

Endothelin consists of a family of potent vasoconstrictor peptides, which include four structurally related isoforms, ET-1, ET-2, ET-3 and vasointestinal contractor (VIC, β -ET)

The antibody shows little cross-reactivity to related peptides and no known cross-reactivity to non-related peptides.

endothelin-1 (ET-1) conjugated to KLH

Monoclonal Anti-Endothelin-1 antibody produced in mouse is suitable for immunoblotting and immunocytochemistry.It is also suitable for radioimmunoassay (RIA) at a working dilution of 1:25,000 and for immunohistochemistry at 1:250 working dilution using formalin-fixed, paraffin-embedded tissue sections.

ET-1, a 21 amino acid peptide, is produced by vascular endothelial cells. It is a potent vasoconstrictor and plays an important role in the homeostasis of the circulatory system. It is also important in pathogenesis of cardiovascular diseases. It is also involved in contraction of airway and intestinal smooth muscle. It releases vasodilator prostaglandins and nitric oxide (NO). It also plays a role in mitogenic effects on vascular smooth muscle cells and fibroblasts, stimulation of atrial natriuretic peptide secretion from atrial cardiocytes and inhibition of renin release. ET-1 is expressed in the spinal cord and dorsal root ganglia, where it may serve as a neurotransmitter/neuromodulator.

Solution in phosphate buffered saline, containing 0.05% sodium azide

200

mouse

unconjugated

purified antibody

primary antibodies

TR.ET.48.5, monoclonal

sheep, human, rat

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:250
radioimmunoassay: 1:25,000
western blot: suitable

IgG1

P05305

dry ice

−20℃

human ... EDN1(1906)

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Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)