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Monoclonal Anti-GDF11, (C-terminal) antibody produced in mouse
| 产品编号： | 3145526 |
| 规格： | clone 3G6, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-GDF11, (C-terminal) antibody produced in mouse
BMP-11
BMP11
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. (provided by RefSeq) |
| Immunogen【免疫原】 | GDF11 (NP_005802, 310 a.a. ~ 407 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence ESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS |
| Biochem/physiol Actions【生化/生理作用】 | As implied by their name, bone morphogenetic proteins (BMPs) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. They also enhance protein degradation and reduce skeletal muscle protein synthesis. BMP-11 may have a role in the development of the nervous system in mice. It acts as a modulator of development and differentiation. In mice, circulating levels of BMP-11 decrease with age. |
| Physical form【外形】 | Solution in phosphate buffered saline, pH 7.4 |
产品性质
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 3G6, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~36.89 kDa |
| species reactivity | human |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable indirect ELISA: suitable |
| isotype【同位素/亚型】 | IgG2bκ |
| NCBI accession no.【NCBI登记号】 | NM_005811 |
| UniProt accession no.【UniProt登记号】 | O95390 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... GDF11(10220) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
