Monoclonal Anti-Intracellular Adhesion Molecule 3 antibody produced in mouse

MFCD01094485

NA.41

The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. The encoded protein is extensively glycosylated and contains five Ig-like domains that share high homology with corresponding domains in ICAM-1 and ICAM-2. ICAM3 is found to be expressed on all leukocytes, including the resting leukocytes. The gene is mapped to human chromosome 19p13.2.

stimulated human leukocytes.

The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. LFA-1 participates in several processes, such as T cell-mediated killing, T helper and B lymphocyte responses, natural killing, Ab-dependent cellular cytotoxicity by monocytes and granulocytes, and adherence of leukocytes to endothelial cells, fibroblasts, and epithelial cells. ICAM-3 mediates the adhesion of resting T lymphocytes to LFA-1 and participates in the initiation of immune responses. It may also function in lymphocyte activation, as well as in adhesion.

Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide.

200

mouse

unconjugated

purified immunoglobulin

primary antibodies

186-2G9, monoclonal

buffered aqueous solution

antigen 120 kDa

human

~1 mg/mL

direct immunofluorescence: 2 μg using 1 mg protein lysate
flow cytometry: 2 μg using 1 mg protein lysate
immunohistochemistry: 2-4 μg/mL using human tonsil tissue sections
immunoprecipitation (IP): 2 μg using 1 mg protein lysate
western blot: 1-5 μg/mL

P32942

wet ice

−20℃

human ... ICAM3(3385)

12 - Non Combustible Liquids