Monoclonal Anti-IRAK antibody produced in mouse

MFCD01092386

NA.41

raised against a recombinant protein corresponding to amino acids 618 - 712 of human IRAK.

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Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

mouse

unconjugated

purified immunoglobulin

primary antibodies

8F1A7, monoclonal

buffered aqueous solution

mouse, human

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

P51617

dry ice

−20℃

Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 2