Monoclonal Anti-MDC1 antibody produced in mouse

NA.41

Mediator of DNA damage checkpoint 1 (MDC1) is a nuclear protein that in humans is encoded by the MDC1 gene mapped to chromosome 6p21.33. The encoded protein is widely expressed in various types of tissues and organs. MDC1 is characterized with two BRCA1 C terminus (BRCT) domain, an N-terminal phosphoamino-acid-binding motif called a forkhead-associated (FHA) domain and large central proline/serine/threonine-rich repeat (PST) domain.

Detects ~184 kDa. This antibody recognizes MDC1 at and around the N-terminus.

GST-tagged recombinant protein corresponding to mouse MDC1 ar and around the N-termius

Mediator of DNA damage checkpoint 1 (MDC1) plays a vital role in stimulation of the intra–S phase and G2-M phase checkpoints of the cell cycle in response to DNA damage. Polymorphism of the gene has been associated with the development of both the serum LDL-cholesterol concentration and hyper–LDL-cholesterolemia. Mammalian MDC1/ nuclear factor with BRCT domain 1 (NFBD1) interacts with phospho-H2AX (γH2AX) and plays a key role in DNA damage response by facilitating normal radioresistance and efficient accumulation of DNA-damage-response proteins on damaged chromatin.

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Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

mouse

unconjugated

purified immunoglobulin

primary antibodies

P2B11, monoclonal

buffered aqueous glycerol solution

antigen predicted mol wt 184 kDa

human, bovine, mouse, chimpanzee

1 mg/mL

indirect immunofluorescence: suitable
western blot: suitable

IgG1

NP_001010833.2

Q14676

wet ice

−20℃

mouse ... MDC1(240087)

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12 - Non Combustible Liquids

WGK 1