Monoclonal Anti-NCOR2 antibody produced in mouse

NA.41

A synthetic peptide from the human SMRT protein corresponding to amino acids 994-1005 (ASASDPHREKTQ) coupled to KLH.

For ChIP: Use 3μl for 10^6 cells. For IHC-Fr: Use at a dilution of 1:50. Immunohistochemical staining of SMRT in HeLa cells with this antibody results in nuclear staining. For WB: Use at a dilution of 1:250. Detects a band of approximately 220-250 kDa (predicted molecular weight: 274 kDa). Optimal dilutions/concentration should be determined by the researcher.

Clone 1212 recognizes the Silencing Mediator for Retinoid and Thyroid receptors (SMRT) gene product, a 168 kDa nuclear protein. Nuclear hormone receptors are transcription factors regulated by ligand binding. In the absence of ligand there is a physical interaction between the nuclear receptors that do not interact with Hsp90 and a family of corepressors which includes SMRT. SMRT helps target histone deacetylases and other components of a multiprotein repressor complex to the specific target promoter to silence gene transcription.

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Phosphate-buffererd saline, pH 7.4, containing no preservatives

mouse

unconjugated

purified immunoglobulin

primary antibodies

1212
monoclonal

liquid

168 kDa

monkey, human

1 mg/mL

ChIP: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable

IgG1

Q9Y618

wet ice

−20℃

human ... NCOR2(9612)

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12 - Non Combustible Liquids