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Monoclonal Anti-Neurofilament 160 antibody produced in mouse
| 产品编号： | 3149119 |
| 规格： | ~2 mg/mL, clone RMO44, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-Neurofilament 160 antibody produced in mouse
Anti-Neurofilament Medium Chain
基本信息
| MDL number | MFCD01322393 |
| NACRES | NA.41 |
| General description【一般描述】 | Neurofilament 160 (NEFM) is one among the most abundant filaments in post-mitotic neurons. Monoclonal Anti- Neurofilament 160 (mouse IgG1 isotype) is derived from the hybridoma RMO44 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified mid-sized rat neurofilament (NF-M) subunit. Neurofilaments are one of the five major groups of intermediate filaments (Ifs) and are found predominantly in cells or tissues of neuronal origin. They are composed of three major proteins of apparent molecular weights 68 kDa, 160 kDa and 200 kDa. |
| Immunogen【免疫原】 | purified mid-sized rat neurofilament (NF-M) subunit. |
| Application【应用】 | Monoclonal Anti-Neurofilament 160 antibody produced in mouse has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | Neurofilament 160 (NEFM) associates with the dopamine receptor. Neurofilament proteins are synthesized in the neuronal perikarya, assembled to form filaments and then slowly transported within the axons towards the synaptic terminals. These molecules undergo post-translational modifications, which results in their heterogeneity including different levels of phosphorylation. The phosphorylation of neurofilament polypeptides has been suggested to modulate their function by influencing their interaction with cytoplasmic organelles. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | RMO44, monoclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | rat, human, mouse, zebrafish |
| concentration【浓度】 | ~2 mg/mL |
| technique(s) | immunohistochemistry: suitable microarray: suitable western blot: 1-2 μg/mL using extract of SHSy5y human neuroblastoma cells |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | P07197 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... NEFM(4741) mouse ... Nefm(18040) rat ... Nefm(24588) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
