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Anti-Notch 1 antibody, Rat monoclonal
| 产品编号： | 3149376 |
| 规格： | clone ICN 5B5, purified from hybridoma cell culture |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Notch 1 antibody, Rat monoclonal
Anti-Notch homolog 1, translocation-associated (Drosophila)
Anti-TAN1, hN1, neurogenic locus notch homolog protein 1
Anti-Translocation-associated notch protein
Monoclonal Anti-Notch 1 antibody produced in rat
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Monoclonal Anti-Notch 1 (rat IgG2b isotype) is derived from the hybridoma ICN 5B5 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a recombinant fusion protein corresponding to a fragment of human Notch 1 fusion protein. Notch receptor 1 (Notch1) gene is located on human chromosome 9q34. |
| Application【应用】 | Monoclonal Anti-Notch 1 antibody produced in rat has been used in immunoblotting. |
| Biochem/physiol Actions【生化/生理作用】 | In chronic obstructive pulmonary disease, notch receptor 1 (Notch1) helps to modulate endothelial apoptosis via the extracellular signal-regulated kinase (ERK) pathway. Overexpression of Notch1 helps to guard endothelial cell from apoptosis. Knockdown of Notch1 results in the enhancement of apoptotic cells. Notch1 serves as a tumor suppressor gene in mammalian epidermis and is a determinant of keratinocyte differentiation. Notch signaling is believed to participate in several human neoplasms including T-cell acute lymphoblastic leukemia. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| biological source【生物来源】 | rat |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| clone【克隆】 | ICN 5B5, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~120 kDa |
| species reactivity | human |
| packaging【包装】 | antibody small pack of 25 μL |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | western blot: 2-4 μg/mL using whole extract of human Jurkat cells and developing with a sensitive film |
| isotype【同位素/亚型】 | IgG2b |
| UniProt accession no.【UniProt登记号】 | P46531 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... NOTCH1(4851) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
